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N.", "National District"), itself bordered on three sides by Santo Domingo Province.
Founded by Bartholomew Columbus in 1496, on the east bank of the Ozama River and then moved by Nicolás de Ovando in 1502 to the west bank of the river, the city is the oldest continuously inhabited European settlement in the Americas, and was the first seat of the Spanish colonial rule in the New World.
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Following his assassination, the city resumed its original designation.
Santo Domingo is the cultural, financial, political, commercial and industrial center of the Dominican Republic, with the country's most important industries being located within the city.
Santo Domingo also serves as the chief seaport of the country.
In 1821 Santo Domingo became the capital of an independent nation after the Criollo bourgeois within the country, led by José Núñez de Cáceres, overthrew the Spanish crown.Expeditions which led to Ponce de León's colonization of Puerto Rico, Diego Velázquez de Cuéllar's colonization of Cuba, Hernando Cortes' conquest of Mexico, and Vasco Núñez de Balboa's sighting of the Pacific Ocean were all launched from Santo Domingo.The original layout of the city and a large portion of its defensive wall can still be appreciated today throughout the Colonial Zone, declared a World Heritage Site by UNESCO.Drake's invasion signaled the decline of Spanish dominion over Hispaniola, which was accentuated in the early 17th century by policies that resulted in the depopulation of most of the island outside of the capital.An expedition sent by Oliver Cromwell in 1655 attacked the city of Santo Domingo, but was defeated.